Department of Population and Public Health Sciences

Preeclampsia Research

Diet and Preeclampsia Risk

A study conducted by investigators at the University of Southern California (MADRES) published in March 2024 evaluated whether 2 previously defined dietary patterns (1) solid fats, refined grains, and cheese or (2) vegetables, oils, and fruit impacted the risk of developing hypertensive disorders of pregnancy (HDP). They also evaluated whether pre-pregnancy body mass index altered the relationship between diet and HDP. The diet containing solid fats, refined grains, and cheese was associated with an almost 4-fold increased risk of developing HDP. In contrast, the diet containing vegetables/oil/fruit resulting in a a 68% reduction in HDP risk. Women who were overweight prior to pregnancy demonstrated a stronger dietary impact on HDP risk.

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Recurrence of Preeclampsia in Subsequent Pregnancies

A recent study investigated recurrence risks for preeclampsia (PE) following a PE-affected pregnancy.  They studied 391,645 women with first and second births between 2006 and 2017. 

They found that women who experienced PE in their first pregnancy had a recurrence rate of 21.5%.  Preterm PE occurred in 5.5% of subsequent pregnancies. 

After considering maternal factors, women with PE in their first pregnancy had more than 14 times the risk in a second pregnancy.  For women who had both PE and continuing hypertension, the odds of PE in the second pregnancy was more than 26 times the risk of developing preterm PE.